科研之友
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摘要
background: american tegumentary leishmaniasis is widely found in brazil; the state of rio de janeiro (capital and hinterland) is an endemic area where the vector is found inside and outside houses. objectives: prospective study of 48 cases attended at the teaching hospital clementino fraga filho - ufrj, between 1990 - 2002. methods: all patients were submitted to skin or mucosa biopsy, montenegro skin test and otorhinolaryngologic examination; sbv (10 - 20 mg/kg) with 10, 30 and 90 doses was used in 44 patients; in 4 cases, amphotericin b (0.5 mg/kg/dose) until cumulative dosage of 30 - 50 mg/kg. results: 28 males and 20 females aged 10 - 89 years mostly infected in rio de janeiro (38 cases/79.1%) mainly presented ulcers in the extremities and involvement of nasal mucosa; 41 cases (85.4%) were reactive to the montenegro skin test (5 mm); 17 cases (35.4%) were positive for amastigotes in tissue sections; an inflammatory chronic granulomatous process was mostly seen. clinical cure was observed in 47 cases; one patient died on day 10 of treatment. conclusion: the study of american tegumentary leishmaniasis (hucff - ufrj) from 1990-2002 showed a well-known %26quot;status%26quot; considering epidemiological and clinical perspectives as well as therapeutic response to antimony (sbv) and amphotericin b.
