Lipoprote赤na (a) en una poblaci車n urbana de Venezuela: evidencia de que su incremento por deprivaci車n estrog谷nica es transitorio

作者：Bermudez Pirela; V; Cabreara de Bravo; M; Mengual Moreno; E; Cano Ponce; C; Leal Gonzalez; E; Lemus Antepaz; M; Amell de Diaz; A; Sorrel Gomez; L

来源：Anales de Medicina Interna, 2007.

DOI：10.4321/S0212-71992007000700004

• lipoprotein (a)
• risk factor
• hormonal replacement therapy
• apo (a)
• tissue plasminogen activator.

background: lipoprotein (a) [lp (a)] is an independent risk factor for coronary artery disease and normal serum levels of this particle is not known in our country. thus, the aim of this study was to determine plasma lp (a) concentration in a population sample of maracaibo. patients and method: fifth hundred out-patients, consulting at centro de investigaciones endocrino-metab車licas %26quot;dr. f谷lix g車mez%26quot; were randomly underwent to venipunction to obtain a fasting blood simple to assess lp (a) by a elisa assay. results: no significantly differences were found when compared by sex or age separately, higher levels in lp (a) was found in female 40-44 year group (median: 20,9 mg/dl). thus, female population was divided in two sub-groups: %26lt; 40 years (median: 13 mg/dl) 40 yr and more (median: 16 mg/dl), finding higher lp (a) levels in the second group (p %26lt; 0,02). hormonal replace therapy was assessed by age, resulting that women subjected this approach shows lower levels of lp (a) (p %26lt; 0,01), except in 60-64 year group. conclusions: lp (a) in a maracaibo was within normal levels. hormonal replace therapy diminishes lp (a) concentration in menopausal women, but in menopausal women without hormonal therapy lp (a) levels experienced a sustained decrease to normal levels in a age-depended manner.