Meta-analysis of risk factors for antibiotic-associated diarrhea in neonates [新生儿抗生素相关性腹泻危险因素的 Meta-分析]

作者：Ding Y.; Peng Z.; Wu S.^*; Wu Q.

来源：Drug Evaluation Research, 2019, 42(4): 753-760.

DOI：10.7501/j.issn.1674-6376.2019.04.031

• antibiotic-associated diarrhea (AAD)
• case-control studies
• Meta-analysis
• neonates
• risk factor

Objective To evaluate the risk factors for antibiotic-associated diarrhea (AAD) in neonates, and to provide evidence-based medical for clinical. Method The related databases of PubMed, Embase, CNKI, CBM, VIP and Wanfang Data were electronically searched for the case-control studies about risk factors for AAD in neonates from January 2010 to May 2018. Meta-analysis was conducted by RevMan 5.2 Software. Results A total of 13 studies involving 4 273 patients were studied, including 915 in the AAD group and 3 358 in the non-AAD group. The result of Meta-analysis showed that, the lower gestational age (SMD=? 0.89, 95%CI= ?1.16~?0.61, P<0.01), lower birth weight (SMD=?0.79, 95%CI=?0.98~?0.59, P<0.01), lower days age (SMD=? 1.08, 95%CI=?1.20~?0.96, P<0.01), combination of antibiotic (SMD=1.59, 95%CI=1.24~1.94, P<0.01), longer hospital stay (SMD =2.21, 95%CI=1.86~2.56, P<0.01), Invasive procedures (OR=2.06, 95%CI=1.85~2.23, P<0.01) and non-pure breastfeeding (OR= 0.47, 95%CI=0.38~9.57, P<0.01) were risk factors for AAD in neonates, and prevention of antibiotic (OR=1.17, 95%CI=0.94~1.46, P>0.05) was no risk factor for AAD in neonates. Conclusion Lower gestational age, lower birth weight, lower age,combination of antibiotics,longer hospital stay, Invasive procedures and non-pure breastfeeding are risk factors for AAD in neonates.

• 单位
  武汉科技大学