科研之友
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摘要
objective: to describe the clinical and therapeutic aspects of pulmonary tuberculosis and compare the adverse effects of the treatment and its outcome in elderly and nonelderly patients. methods: this was a case-control study of 117 elderly individuals (over the age of 60 years) and 464 nonelderly individuals (aged 15-49 years). all subjects presented pulmonary tuberculosis that had been diagnosed and treated at the thoracic diseases institute of the federal university of rio de janeiro between 1980 and 1996. results: in the elderly group, pulmonary tuberculosis was found to be correlated with diabetes (or = 3.98; 95% ci = 2.07-7.65; p = 0.001), lung disease (or = 7.24; 95% ci = 3.64-14.46; p = 0.001) and heart disease (or = 5.86; 95% ci = 2.88-11.95; p = 0.001). smoking (or = 2.07; 95% ci = 1.26-3.42; p = 0.002) and alcohol abuse (or = 1.63; 95% ci = 1.01-2.68; p = 0.041) were also more common in the elderly group. in the elderly group, the treatment more frequently resulted in adverse reactions (or = 1.62; 95% ci = 1.04-2.54; p = 0.024), especially gastrointestinal reactions (or = 1.64; 95% ci = 1.01-2.77; p = 0.047), and treatment efficacy was lower: cure rate, 51%; mortality rate, 24%. treatment adherence was low (approximately 77%) in both groups. conclusions: in the elderly group, adverse reactions were more common, treatment outcomes were less favorable, there was a greater frequency of clinical complications and deaths related to drug toxicity, and the prevalence of concomitant diseases was higher.
