Influ那ncia da t谷cnica de pressˋo expirat車ria positiva oscilante e da t谷cnica de expiraˋˋo forˋada na contagem de c谷lulas e quantidade do escarro induzido em portadores de asma ou doenˋa pulmonar obstrutiva crˋnica

作者：Morsch; Ana Lucia Bernardo de Carvalho; Amorim; Maria Marta; Barbieri; Andrea; Santoro; llka Lopes; Fernandes; Ana Luisa Godoy

来源：Jornal Brasileiro de Pneumologia, 2008.

DOI：10.1590/S1806-37132008001200007

• asthma
• pulmonary disease
• obstructive chronic
• sputum
• physical therapy modalities.

objective: to evaluate whether respiratory therapy techniques influence the number of cells within and quantity of induced sputum in patients with asthma or chronic obstructive pulmonary disease (copd). methods: randomized clinical trial, in which patients with asthma or copd under intervention (n = 16 and 10, respectively) were compared with control groups (n = 16 and 10). patients in the asthma/intervention (a/i) and copd/intervention (c/i) groups were submitted to oscillating positive expiratory pressure maneuvers for 5 min, followed by 10 forced expiratory technique sequences. these patients were also submitted to an induced sputum protocol with inhaled hypertonic saline (3%, 4% or 5%; a/i group) or inhaled isotonic saline (c/i group). the asthma/control (a/c) and copd/control (c/c) groups were submitted only to the standard induced sputum protocol. results: the final mean weight of the sputum samples was significantly greater in the a/i group than in the a/c group (2,767.25 ㊣ 998.08 mg vs. 1,689.17 ㊣ 1,189.96 mg; p = 0.03). the mean/median total cell counts (℅106/ml) were higher in the a/i and c/i groups than in the a/c and c/c groups (4.06/0.95 and 0.63/0.39, p = 0.05, vs. 5.08/1.77 and 0.64/0.40, p = 0.02). there were no statistically significant differences among the groups in terms of cell viability. conclusions: the use of respiratory therapy techniques can increase sputum sample weight in asthma patients, as well as increasing total cell counts in patients with asthma or copd.