科研之友
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摘要
Malignant tumors and infectious diseases are two main threats to human beings.Photodynamic therapy(PDT)is an effective approach to treat malignancies and infections through the generation of reactive oxygen species(ROS)of a non-toxic photodynamic drug(photosensitizing agent)upon light irradiation.PDT shows promising in treating areas where light can reach,for example,skin and cavities.To treat the problems on deep tissues,much evidence has accumulated in recent years suggesting that sonodynamic therapy(SDT),which eradicates malignant or infectious cells by ROS produced from the interaction of ultrasound energy and sonodynamic drug(sonosensitizing agent),has potential in treating diseases in deep tissues because ultrasound energy has deeper tissue penetration than light energy.Natural products are a valuable source for developing novel drugs.In recent years,we are focusing on developing novel and naturally occurring photodynamic and sonodynamic agents.We have found some active components from natural products,for example,curcumin and hypocrellin,have not only photodynamic activity and also sonodynamic activity in killing bacterial and tumor cells.This talk will briefly introduce two new technologies including photodynamic and sonodynamic therapy,and highlight the recent development in photodynamic and sonodynamic drugs from natural products or traditional Chinese medicines.Chemical modifications of the active compounds have also been attempted to achieve better results.
