Post-Assembly Modification of Homochiral Titanium-Organic Cages for Recognition and Separation of Molecular Isomers

作者：Chen, Guang-Hui; He, Yan-Ping; Yu, Yinghua; Lv, Hong; Li, Shangda; Wang, Fei; Gu, Zhi-Gang; Zhang, Jian^*

来源：Angewandte Chemie - International Edition, 2023, 62(16): e202300726.

DOI：10.1002/anie.202300726

• Chiral Cage-Based Frameworks
• Post-Assembly Modification
• Recognition and Separation
• Titanium-Organic Cages

A chiral metal-organic cage (MOC) was extended and fixed into a porous framework using a post-assembly modification strategy, which made it easier to study the host-guest chemistry of the solid-state MOC using a single-crystal diffraction technique. Anionic Ti4L6 (L=embonate) cage can be used as a 4-connecting crystal engineering tecton, and its optical resolution was achieved, thus homochiral Delta Delta Delta Delta- and ????-[Ti4L6] cages were obtained. Accordingly, a pair of homochiral cage-based microporous frameworks (PTC-236(Delta) and PTC-236(?)) were easily prepared by a post-assembly reaction. PTC-236 has rich recognition sites provided by the Ti4L6 moieties, chiral channels and high framework stability, affording a single-crystal-to-single-crystal transformation for guest structure analyses. Thus it was successfully utilized for the recognition and separation of isomeric molecules. This study provides a new approach for the orderly combination of well-defined MOCs into functional porous frameworks.

• 单位
  中国科学院大学; 结构化学国家重点实验室; 中国科学院福建物质结构研究所