DSCR 1‐mediated TET 1 splicing regulates miR‐124 expression to control adult hippocampal neurogenesis

作者：Chiyeol Choi; Taehoon Kim; Karen T Chang; Kyung‐Tai Min

来源：The EMBO Journal, 2019, 38(14).

DOI：10.15252/embj.2018101293

• Adult hippocampal neurogenesis
• Down syndrome
• DSCR1
• TET1
• MiR‐124

Abstract(#br)Whether epigenetic factors such as DNA methylation and micro RNA s interact to control adult hippocampal neurogenesis is not fully understood. Here, we show that Down syndrome critical region 1 ( DSCR 1) protein plays a key role in adult hippocampal neurogenesis by modulating two epigen...