Uma rara causa de dispn谷ia com apresentaˋˋo singular na tomografia computadorizada de t車rax: s赤ndrome de ativaˋˋo macrof芍gica

作者：Brando Neto; Rodrigo Antnio; Santana; Alfredo Nicodemos Cruz; Danilovic; Debora Lucia Seguro; Bernardi; Fabiola Del Carlo; Barbas; Carmen Silvia Valente; Mendona; Berenice Bilharinho de

来源：Jornal Brasileiro de Pneumologia, 2008.

• macrophage activation
• lymphohistiocytosis
• hemophagocytic
• tomography
• x-ray computed
• lung diseases
• interstitial.

macrophage activation syndrome is a rare and potentially life-threatening disease. it occurs due to immune dysregulation manifested as excessive macrophage proliferation, typically causing hepatosplenomegaly, pancytopenia and hepatic dysfunction. here, we report an unusual case of macrophage activation syndrome presenting as dyspnea, as well as (reported here for the first time) high resolution computed tomography findings of an excavated nodule, diffuse ground glass opacities and consolidations (mimicking severe pneumonia or alveolar hemorrhage). the patient was successfully treated with human immunoglobulin. we recommend that macrophage activation syndrome be considered in the differential diagnosis of respiratory failure. rapid diagnosis and treatment are essential to achieving favorable outcomes in patients with this syndrome.