科研之友
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摘要
pigmented mammary paget%26apos;s disease is a rare dermatosis, with approximately 12 reported cases in the literature, which can mimic cutaneous melanoma both clinically and histologically. as for classical mammary paget%26apos;s disease, the pigmented variant is associated with neoplasia of the breast, originating mainly from intraductal mammary carcinoma that extends to the epidermis of the nipple and areola through a lactiferous duct. physiopathology of hyperpigmentation remains unknown. we present a 49-year-old female patient who presented with a pigmented lesion of the nipple suspected of melanoma. histological examination was not sufficient to confirm diagnosis. immunohistochemical examination confirmed the diagnosis of paget%26apos;s disease. although uncommon, pigmented paget%26apos;s disease must be reminded as a differential diagnosis of melanoma in pigmented lesions of the nipple, in both genders.
