正交试验法优选穿心莲内酯硫酸酯化反应工艺

作者：许卉; 王功富; 刘珂; 付颖颖; 杨小玲

来源：化学研究与应用, 2008, (11): 1480-1482.

• 穿心莲内酯
• 硫酸酯化反应
• 正交试验
• 综合评分法

An orthogonal-design experiment with the type of L9(34) is applied to optimize the condition for sulfonation of andrographolide with concentrated sulfuric acid.The optimal sulfonation condition is established by general analysis of reacting percentage of sulfonation agent and the yield of main aim p...

• 单位
  江西青峰药业有限公司; 烟台大学