科研之友
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摘要
objective: to determine primary and acquired resistance to pyrazinamide in mycobacterium tuberculosis strains isolated in sputum samples from patients with pulmonary tuberculosis. methods: this was a prospective, descriptive study conducted between april and november of 2011 at a referral hospital for tuberculosis in the city of recife, brazil. cultures, drug sensitivity tests, and tests of pyrazinamidase activity were conducted in a private laboratory in recife. results: of the 71 patients included in the study, 37 were treatment-naˋve and 34 represented cases of retreatment. pyrazinamide-resistant strains were isolated in 14 (41.2%) of the 34 patients who had previously been treated for tuberculosis and in none of the 37 treatment-naˋve patients. of the 14 isolates, 10 (90.9%) tested negative for pyrazinamidase activity. a total of 60 isolates tested positive for pyrazinamidase activity. of those, 56 (93.3%) were found to be sensitive to pyrazinamide. conclusions: the high frequency of pyrazinamide-resistant strains (41.2%) in patients previously treated for tuberculosis highlights the need for drug susceptibility testing prior to the adoption of a new treatment regimen.
