Probiotics supplementation for management of type Ⅱ diabetes risk factors in adults with polycystic ovarian syndrome:a meta-analysis of randomized clinical trialOA

作者：Chengcheng Zhang; Yingyue Sheng; Jinchi Jiang; Yuzheng Xue; Leilei Yu; Fengwei Tian; Jianxin Zhao; Hao Zhang; Jian Jin^*; Qixiao Zhai^*

来源：Food Science and Human Wellness, 2023, 12(04): 1053-1063.

This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome(PCOS).The meta-analysis was performed in accordance with the Cochrane Handbook guidelines and relevant the preferred reporting items for systematic reviews and meta-analyses(PRISMA) statement criteria.Of 825 identified reports,11 randomized clinical trials were included in the meta-analysis.An analysis of pooled extracted data revealed that supplementation with probiotics significantly decreased fasting blood glucose(FBG,n = 7;standardized mean difference(SMD) =-0.40;95% confidence interval(CI):-2.02,-0.02;P = 0.04) and insulin levels(n = 6;SMD =-0.57;95% CI:-0.89,-0.25;P = 0.000 4) and the homeostatic model assessment of insulin resistance(n = 7;SMD =-0.64;95% CI:-0.96,-0.31;P = 0.000 1) while increasing the quantitative insulin sensitivity check index(QUICKI,n = 5;SMD = 0.58;95% CI:0.08,1.09;P = 0.02) in patients with PCOS.The FBGreducing effect decreased as the baseline body mass index(BMI) and mean age of the participants increased.Indeed,a greater number of bacterial species and a higher bacterial dose were shown to reduce QUICKI effectively.The systematic review indicated that probiotic supplementation may help to control glucose homeostasis in adults with polycystic ovarian syndrome.

• 单位
  食品科学与技术国家重点实验室; 江南大学