MiR‐16‐5p is frequently down‐regulated in astrocytic gliomas and modulates glioma cell proliferation, apoptosis and response to cytotoxic therapy

作者：A Krell; M Wolter; N Stojcheva; C Hertler; F Liesenberg; M Zapatka; M Weller; B Malzkorn; G Reifenberger

来源：Neuropathology and Applied Neurobiology, 2019, 45(5): nan.12532.

DOI：10.1111/nan.12532

• Apoptosis
• Glioma
• Proliferation
• Temozolomide resistance

Aims(#br)Aberrant expression of microRNAs (miRNAs) is frequent in various cancers including gliomas. We aimed to characterize the role of miR‐16‐5p as a candidate tumour suppressor miRNA in gliomas.(#br)Methods(#br)Real‐time PCR‐based approaches were used for miRNA and mRNA expression profiling of g...