科研之友
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摘要
objective: to discuss the high prevalence of sickle cell disease in our environment and the increased morbidity and mortality as a result of infection associated with this condition. sources of data: review of medline from 1986 to 2003. we found around 600 references about the subject. thirty-five journal articles were reviewed, in addition to chapters in two text books. summary of the findings: we discuss general information concerning sickle cell disease as well as a few topics about the most frequently observed infections in these patients. drug prophylaxis and immunizations are also covered. conclusions: this review hopes to provide the pediatric community with information concerning the association between sickle cell disease and infections, so as to minimize the occurrence of complications.
