科研之友
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摘要
introduction: pleomorphic adenomas (pa) are the most common histologic type of salivary gland tumors. malignant transformation may occur in the setting of recurrent or longstanding disease. objective: evaluate the clinicopathologic characteristics of pa of the major salivary glands, particularly tumors showing signs of malignant transformation. material and methods: the clinical and histopathologic characteristics of 106 cases of pa were evaluated retrospectively. results: the mean patient age was 39.5 years. there was a predominance of female patients (69.5%). the parotid was the most commonly affected gland (86.8%). the tumor had been present for over a year in 76.74% of the cases, with a mean size of 3.48 cm. histologic examination revealed a thin and incomplete capsule in 49% of the cases; however, protrusions into the capsule or extracapsular extension were infrequent (11.32% and 8.49%, respectively). the extracellular matrix varied from myxochondroid (41.5%), myxoid (36.8%), chondroid (3.8%) and fibrotic (1.9%); coexisting patterns were observed. the myoepithelial-epithelial component corresponded to 50% or more of the tumor in 65.1% of the cases, and was solid (40.6%), cystic (20.7%), arranged in cords (86.8%), ducts (81.1%) and had a palisading configuration (8.49%). squamous metaplasia was present in 16.04% of the cases. features associated with malignant transformation were incommon: extensive hyalinization (4,7%) and necrosis (0,9%). conclusion: the histopathologic diversity of pa was confirmed. features associated to malignant transformation were unfrequent.
