科研之友
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摘要
Prohibitins (PHBs) are important proteins that evolve conservatively. The Prohibitin domain family contains two homologous subtypes of PHB1 and PHB2 in mammalian cells. PHBs involve a variety of cellular functions, including cell proliferation, cell migration and cell apoptosis. The subcellular localization of PHBs determines that they perform different functions. The PHBs distributed on membranes can regulate membrane transport, cell proliferation and migration, the PHBs in the nucleus can regulate gene transcription and cell cycle, the PHBs located in the mitochondrial inner membrane can maintain the mitochondrial genome and mitochondrial morphology, and are involved in mitochondrial pathways of apoptosis. Moreover, as an important medium, PHB proteins can " shuttle" between the nucleus and mitochondria. In recent years, with the deepening of the research on PHBs, we can find that PHBs are closely related to occurrence and development of multiple types of tumors. This paper gives a general review from structure and localization of proteins, as well as their functions focusing on the roles of PHBs in occurrence, development, migration and apoptosis of tumors. It lays a theoretical foundation for further revealing the molecular mechanism of PHBs and in the development of different types of tumors to work on more efficient drug targets.
