聚(N-异丙基丙烯酰胺-共-苯并-18-冠-6丙烯酰胺)共聚高分子的醇和离子综合响应性能(英文)

作者：巨晓洁; 皮硕伟; 谢锐; 郭晓静; 柳杰译; 余亚兰; 江潞; 陆小华; 陈谦明; 褚良银

来源：Chinese Journal of Chemical Engineering, 2014, 22(09): 1038-1045.

• Stimuli-responsive material Phase transition behavior Alcohol-responsive property Ion-responsive property

In this paper, we report on the comprehensive alcohol-/ion-responsive properties of a smart copolymer poly(Nisopropylacrylamide-co-benzo-18-crown-6-acrylamide)(P(NIPAM-co-BCAm)). The orthogonal design method is adopted for experimental design. The experimental results show that alcohol can trigger the shrinking and Ba2+can induce the swelling of the P(NIPAM-co-BCAm) copolymer. According to the phase transition temperature(LCST) change results of the copolymer, the influence of variables on the LCST changes weakens in the following order: alcohol concentration N alcohol species N metal ion species N BCAm concentration N ion concentration. The larger the alcohol concentration and the larger the molecular size of alcohols, the lower the LCST value; on the contrary, the more the BCAm content in the copolymer or the larger the BCAm/ion complex stability constant(lgK) or the larger the ion concentration is, the higher the LCST value. For a P(NIPAM-co-BCAm)copolymer with a fixed BCAm content, a binary function of ion concentration and lgK of BCAm/ion is developed to precisely predict the LCST values of the copolymer in different metal ion solutions. The results provide valuable information for fabricating artificial biomimetic G-protein-gated inwardly rectifying potassium(GIRK) channels that are activated by alcohol and inhibited by Ba2+.

• 单位
  四川大学; 口腔疾病研究国家重点实验室; 材料化学工程国家重点实验室