Complexes of platinum(II/IV) with 2-phenylpyridine derivatives as a new class of promising anti-cancer agents

作者：Tan, Ming-Xiong; Wang, Zhen-Feng; Qin, Qi-Pin^*; Huang, Xiao-Ling; Zou, Bi-Qun; Liang, Hong

来源：Inorganic Chemistry Communications, 2019, 108: 107510.

DOI：10.1016/j.inoche.2019.107510

• 2-(4-Trifluoromethylphenyl)pyridine
• Platinum complex
• Cell apoptosis
• Mitochondria dysfunction

Four platinum(II/IV) complexes, [Pt-IV (PPy)(2)Cl-2]-CH3OH (Pt1), (Pt-IV(TFPy)(2)Cl-2) (Pt-2), [Pt-II(MPy)(H-MPy)Cl] (Pt3), and [Pt-II(DPPy)(H-DPPy)Cl] (Pt4) with 2-phenylpyridine (H-PPy), 2-(4-trifluoromethylphenyl)pyridine (H-TFPy), 3-methyl-2-phenylpyridine (H-MPy) and 2,5-diphenylpyridine (H-DPPy) were first designed and prepared. Cytotoxic properties of Pt1-Pt4 were evaluated in human tumor HeLa (cervical), MCF-7 (breast), Hep-G2 (hepatoma), T-24 (bladder) cells and HL-7702 nontumorigenic cells by means of the MTT assay. The four Pt complexes Pt1-Pt4 were more selective for HeLa (cervical) cells versus normal HL-7702 cells. Remarkably the most active Pt2 compound, having 2-(4-trifluoromethylphenyl)pyridine (H-TFPy) ligand, showed IC50 values down to 1.01 +/- 0.34 mu M. Importantly, Pt1 and Pt2 induce apoptosis in T-24 (bladder) cells via ROS-mediated mitochondria dysfunction.

• 单位
  玉林师范学院; 桂林师范高等专科学校; 广西师范大学