科研之友
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摘要
background: superficial and subcutaneous mycoses have a high prevalence and, often, chronic evolution. therefore, they need extensive treatment with topic and/or systemic antifungal agents. azoles and alilamines (terbinafine) are first-choice drugs to treat human and animal infections. thus, evaluation of the efficacy of these drugs is important for a successful treatment. however, there are few studies that evaluate the in vitro activity of antifungal agents. objective: to evaluate the in vitro efficacy of terbinafine activity against filamentous fungi and yeasts that cause mycoses. method: the in vitro activity of terbinafine (0.125-100米g) against 10 fungi species was evaluated by the diskdiffusion and microdilution/reference methods to determine the minimum inhibitory concentration (mic). results: we found a high susceptibility to terbinafine in: t. rubrum, m. gypseum, t. mentagrophytes, t. tonsurans, m. canis, c. carrionii and e. floccosum (halo ≡ 40mm with 0.125米g disk). s. hyalinum and c. parapsilosis were considered susceptible, but less than the others. fusarium spp. showed the lowest susceptibility (halo=12mm with 2米g disk; mic 8米g/ml). conclusions: the results of this research confirm previous findings about the efficacy of terbinafine. the drug was shown to be highly effective to treat dermatophyte infections. the disk-diffusion method was easy to use and is a suitable technique for routine use in clinical laboratories.
