EVALUATION OF IL1-汐 AND TNF-汐 SERUM LEVELS IN RHEUMATOID ARTHRITIS PATIONTS WITH ACTIVE AND INACTIVE, WITH OR WITHOUT BONE EROSION

作者：AR Rostamian; AH Naji; F Gharibdoost; A KHalvat

来源：Acta Medica Iranica, 2007.

• cytokins

Rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. Several studies in recent years were conducted for evaluation of inflammatory cytokines such as IL1-汐 (Interlukin 1汐) and TNF- 汐 (Tumor necrosis factor) in rheumatologic disorders including rheumatoid arthritis to find new treatment methods base to pathogenesis. In this study different serum levels of IL1-汐 and TNF- 汐 in 160 rheumatoid arthritis patients with active and inactive disease and also disease with or without bone erosion are assessed. 4% of our patients had rheumatoid nodule and 70% of all patients had positive RF, IL1-汐, and TNF- 汐 levels. Active with bone erosion patients had IL1-汐 and TNF- 汐 serum levels higher than active without bone erosion patients; it was not significant in T-test but it was significant in Mann-Whitney Test. The results was the same as expected; IL1-汐, and TNF- 汐 serum levels were higher in active with bone erosion in comparison with inactive without bone erosion patients.