Neuroprotective Effect of Dexamethasone on the Morphology of the Irradiated Post Natal Developing Cerebellum of Wistar Rat (Rattus norvegicus) Efecto Neuroprotector de la Dexametasona sobre la Morfolog赤a del Cerebelo Postnatal en Desarrollo Irradiado de Rata Wistar (Rattus norvegicus)

作者：A O Malomo; O E Ekpo; I O Imosemi; O Owoeye

来源：International Journal of Morphology, 2006.

• Morfologia
• Irradiacion
• Dexametasona
• Desarrollo del cerebelo
• Morphology
• Irradiation
• Dexamethasone
• Developing cerebellum

The neuroprotective effect of dexamethasone on the irradiated postnatal developing cerebellum of Wistar rat was studied. Seventy-five (day 1 old) neonates were separated into three groups; control group receiving no drug and no irradiation, irradiated group, and irradiated and dexamethasone group in which the dexamethasone was administered one hour before exposure to 5Gray (5Gy) of gamma rays. On complete exposure to the various interventions, the cerebellar tissues of animals from each group on days 5, 9, 14, 21 and 25 were processed for histological and histomorphometric studies. The result of the study showed that irradiation alone significantly reduced the thickness of the external granular layer (EGL) on day 5 and 14 at P0.05. Histologically, the cells of the ML in the irradiated group on days 9 and 14 were heavily gliosed compared to the mildly gliosed control, and the irradiated and dexamethasone groups. There was distortion of the PC monolayer with some cells found in either the ML or GL in the irradiated group on days 5, 9, 14 and 25. From the result of the study, administration of 0.005ml dexamethasone intraperitoneallyone hour before exposure to irradiation appeared to protect the developing rat cerebellum against irradiation injury as seen when compared with the controls Se estudi車 el efecto neuroprotector de la dexametasona, sobre el cerebelo post-natal en desarrollo irradiado de ratas Wistar. 75 neonatos de 1 d赤a de edad fueron separados en 3 grupos; el grupo control no recibi車 ni drogas ni irradiaci車n, un grupo irradiado y el otro irradiado con aplicaci車n de dexametasona. Esta droga fue administrada una hora antes de la exposici車n de 5Gray (5Gy) de rayos gamma. El tejido cerebelar de cada grupo con 5, 9, 14, 21 y 25 d赤as fueron procesados para estudios histol車gicos e histomorfom谷tricos. El resultado del estudio demostr車 que la sola irradiaci車n redujo significativamente el grosor de la capa granular externa, en los grupos con 5 y 14 d赤a,s con un p0,05; la capa molecu