科研之友
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Reprogramming Tumor‐Associated Macrophages(#br)In article number 2108971, Zhen Li and co‐workers find that ultra‐small Cu2?xSe nanoparticles can effectively polarize tumor‐associated macrophages (TAMs) from the tumor‐supportive M2 phenotype into anti‐tumor M1 phenotype to significantly boost anti‐tumor immunity through a novel mechanism. The nanoparticles can generate reactive oxygen species to trigger polarization through the novel ROS‐TRAF6‐IRF5‐IL‐23 signaling pathway, rather than the classic ROS‐NF‐?B‐iNOS pathway.
