A novel surface plasmon resonance sensor based on a functionalized graphene oxide/molecular-imprinted polymer composite for chiral recognition of l-tryptophan

作者：Xu, Xiaoyan; Zhang, Yi; Wang, Bingfeng; Luo, Lin; Xu, Zhenlin; Tian, Xingguo^*

来源：RSC Advances, 2018, 8(57): 32538-32544.

DOI：10.1039/c8ra06295a

• ELECTROCHEMICAL SENSOR
• GOLD NANOPARTICLES
• OXIDE
• SEPARATION
• DOPAMINE
• NANOCOMPOSITES
• BIOSENSOR
• ELECTRODE
• SCIENCES
• TYROSINE

Herein, a novel surface plasmon resonance (SPR) sensor based on a functionalized graphene oxide (GO)/molecular-imprinted polymer composite was developed for the chiral recognition of l-tryptophan (l-Trp). The composite's recognition element was prepared via a facile and green synthesis approach using polydopamine as both a reducer of GO and a functional monomer as well as a cross-linker for molecular imprinting. The composite was characterized via Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction, and Raman spectroscopy. After attaching the composite onto the gold surface of an SPR chip, the sensor was characterized using contact-angle measurements. The sensor exhibited excellent selectivity and chiral recognition for the template (i.e., l-Trp). Density functional theory computations showed that the difference in hydrogen bonding between the composite element and l-Trp and d-Trp played an important role in chiral recognition.

• 单位
  华南热带农业大学; 华南农业大学