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摘要
OBJECTIVE To provide recommendations for the individualized dosage of posaconazole, the data of posaconazole plasma trough concentration (Cmin) in children with malignant hematologic disorders were evaluated, and the factors impacting the Cmin were discussed. METHODS From March 2021 to January 2023, clinical data of children with hematologic malignancies were collected, and the effects of age, sex, weight, diarrhea, and combined medication on the Cmin of posaconazole were analyzed. RESULTS A total of 39 pediatric patients who met the criteria were enrolled, and 130 Cmin monitoring data were collected, of which 70 cases had posaconazole Cmin>0.7 mg·L-1, and the compliance rate was 53.8%. Posaconazole Cmin was significantly correlated with patient weight, administered dose, combined proton pump inhibitors, and specific pathological status (vomiting, diarrhea, and liver function). CONCLUSION There are many factors affecting posaconazole Cmin in children with hematologic malignancies, so close therapeutic drug monitoring should be conducted, and posaconazole dosing regimen should be adjusted according to body weight, combined proton pump inhibitors and special pathological status to ensure the effectiveness and safety of posaconazole. ? 2023 Editorial Office of Chinese Journal of Hospital Pharmacy.
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