结直肠癌趋化因子MCP-1的表达及其与巨噬细胞浸润的关系The expression of chemokine MCP-1 in colorectal carcinoma and its relationship to the infiltration of macrophage

作者：杨春康; 陈道达; 黄凯; Huihao Zhang; Dongpo Xu; Yuan Tian; Jinhui Zhang

来源：The Chinese-German Journal of Clinical Oncology, 2006, 5(5): 343-346.

• colorectal neoplasm
• chemokine
• MCP-1
• macrophage

Objective: To study the expression of MCP-1 in colorectal carcinoma and its relationship to the infiltration of the macrophage and to the biological behaviour of infiltration and metastasis of colorectal carcinoma.Methods: The expression of the MCP-1 mRNAwas assessed in colorectal carcinoma collected freshly from surgical specimen by RT-PCR and the expression of the MCP-1 protein was assessed in colorectal carcinoma collected from surgical specimen by immunohistochemistry.The tumor infiltrating cell and macrophage were also investigated by immunohistochemistry.Results: All the 12 specimens of colorectal carcinoma detected by RT-PCR expressed the MCP-1 mRNA; MCP-1 protein was detected in 90% (36/40) cases of the tumor; The expression of the MCP-1 protein in colorectal carcinoma correlated negatively with its state of metastasis and the Dukes' stage.But a postive correlation was found between the expression of MCP-1 and the infiltrated macrophage.The stronger expression of MCP-1,the more number of the infiltrated macrophage.Conclusion: The expression of chemokine MCP-1 in colorectal carcinoma may influence its biological behaviour of infiltration and metastasis,and can attract the immuno-cell to the local of the tumor,such as Macrophage.

• 单位
  福建医学院; 华中科技大学