科研之友
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摘要
objective: to determine the prevalence of celiac disease and to describe the histological alterations, clinical manifestations, and conditions associated with a group of first-degree relatives of celiac disease patients in the municipality of recife, northeast brazil. method: the study was conducted in outpatient clinics of pediatric gastroenterology located in recife. we included in the study 174 first-degree relatives who were screened for the anti-transglutaminase iga antibody. those relatives who had positive serological tests were invited to undergo a small intestine biopsy (classified according to marsh). they were also evaluated regarding weight, height, clinical symptoms and conditions associated with celiac disease. the chi-square test and fisher%26apos;s exact test were used to assess the differences with a significance level of p %26lt; 0.05. results: the anti-transglutaminase iga antibody was positive for 20.1% (34/174) of the relatives (95%ci 14.6-26.5). there was no difference in terms of positive serological tests regarding either degree of kinship or sex. twenty-two patients underwent biopsy. thirteen had histological alterations classified as marsh stage 3; seven had stage 1; and two had stage zero, with a probable prevalence of 11.5%. all patients, except for one, had symptoms; the only patient with no symptoms was short. conclusion: celiac disease prevalence in this group of relatives was high. all new cases identified were symptomatic or had associated conditions. in this group, there was a high frequency of individuals with positive serological tests, symptoms suggestive of celiac disease, and no evidence of villous atrophy in the intestinal mucosa.
