Detection of human parvovirus B19 in cases of hydrops fetalis in Sˋo Paulo, Brazil

作者：Figueiredo; Cristina Adelaide; Oliveira; Maria Isabel de; Afonso; Ana Maria Sardinha; Andrade; Joelma Queiroz; Brizot; Maria de Lourdes; Zugaib; Marcelo; Curti; Suely Pires

来源：Jornal Brasileiro de Patologia e Medicina Laboratorial, 2008.

DOI：10.1590/S1676-24442008000600005

• human parvovirus b19
• prenatal diagnosis
• hydrops fetalis
• ultrasound.

human parvovirus b19 infection is known to be one of the causes of hydrops fetalis. the maternal infection caused by the virus may be symptomatic or asymptomatic. in this study, 40 pregnant women with gestational age of approximately 25 weeks, prenatal diagnosis of non immune hydrops fetalis and suspected of human parvovirus b19 infection were studied between january 1999 and december 2005. serology results and detection of dna in the maternal serum, foetal serum and amniotic fluid confirmed that 20 pregnant women had been infected by human parvovirus b19. the ultrasound examination demonstrated foetal hydrops, anaemia, hepatosplenomegaly, ascites, cardiopathy and amniotic fluid disorders. among the positive cases, there were three fatal losses, one by miscarriage and two by intrauterine foetal death.