科研之友
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摘要
Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reacting oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction, and that the embryonic processes regulating the balance of ROS formation, oxidative DNA damage and repair, and ROS-mediated signal transduction may be important determinants of teratological risk. ROS can oxidize molecular targets such as DNA, protein, lipid in a process called oxidative stress resulting in cellular dysfunction and in utero death or teratogenicity. This review, consisting of literature search of journals and chapters in books aims at highlighting the importance of the cerebellum in controlling various motor activities in the body, as well as substances affecting cerebellar development with a view of providing an insight to the role antioxidants play in cerebellar development. It is interesting to note that the developing brain (especially the cerebellum, cerebrum and hippocampus) is highly vulnerable to the deleterious effects of ROS. Studies have shown that exposure to oxidants in the first trimester is associated with an increased risk of major congenital anomalies, as most vital organs in the body develop and some become functional within this period in offspring. Antioxidants may prevent oxidative damage in degenerative diseases including ageing, cardiovascular diseases, cancer, Alzheimer%26apos;s disease, stroke and Parkinson%26apos;s disease as such play a critical role in wellness and health maintenance. Las patolog赤as del desarrollo pueden resultar de la formaci車n end車gena o xenobi車tica de especies reactivas de ox赤geno (ROS), que da an oxidativamente macromol谷culas celulares y/o alteran la transducci車n de se ales, y los procesos embrionarios que regulan el equilibrio de la formaci車n de ROS, da o oxidativo y reparaci車n del ADN; la transducci車n de se ales mediada por ROS pueden ser determinantes e importantes del riesgo teratol車gico. Las ROS pueden oxidar blancos moleculares como el ADN, prote赤nas y l赤pidos en un proceso llamado estr谷s oxidativo que resulta en disfunci車n celular y muerte intrauterina o teratogenicidad. Esta revisi車n consiste en la b迆squeda bibliogr芍fica de art赤culos y cap赤tulos de libros con el objetivo de destacar la importancia del cerebelo en el control de diversas actividades motoras del cuerpo, as赤 como las sustancias que afectan el desarrollo de 谷l con el fin de proporcionar una visi車n del rol que juegan los antioxidantes en el desarrollo del cerebelo. Es interesante observar que el enc谷falo en desarrollo (especialmente el
