Multiple roles of silver salts in palladium-catalyzed C–H activations

作者：Katherine L. Bay; Yun-Fang Yang; K.N. Houk

来源：Journal of Organometallic Chemistry, 2017.

• C-H activation
• Pd catalysis
• Ag salts
• Bimetallic catalysis
• Pd-Ag cooperativity
• Heterometallic synergism

Many Pd-catalyzed C–H functionalization reactions utilize stoichiometric Ag(I)-salts as additives. Ag additives are typically used either as a terminal oxidant or as a halide scavenger for Pd catalyst regeneration. However, recent experimental and computational studies have shown that Ag(I)-salts may play additional roles in C–H activation processes. Notably, cooperative Pd–Ag bimetallic C–H activations and Ag(I)-mediated Pd-catalyzed C–H arylations can occur. The non-oxidative roles of Ag(I) salts in Pd-catalyzed C-H activation are highlighted in this mini-review.
Graphical abstract

Download high-res image (92KB)Download full-size image