Direct Access to Aryl Bis(trifluoromethyl)carbinols from Aryl Bromides or Fluorosulfates: Palladium‐Catalyzed Carbonylation

作者：Katrine Domino; Cedrick Veryser; Benjamin A Wahlqvist; Cecilie Gaardbo; Dr Karoline T Neumann; Prof Dr Kim Daa**jerg; Prof Dr Wim M De Borggraeve; Prof Dr Troels Skrydstrup

来源：Angewandte Chemie, 2018, 130(23): 6974-6978.

DOI：10.1002/ange.201802647

• Arylhalogenide
• Carbonylierungen
• Fluor
• Isotopenmarkierung
• Palladium

Abstract(#br)A palladium‐catalyzed carbonylative approach for the direct conversion of (hetero)aryl bromides into their α,α‐bis(trifluoromethyl)carbinols is described, and it employs only stoichiometric amounts of carbon monoxide and trifluoromethyltrimethylsilane. In addition, aryl fluorosulfates p...