科研之友
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摘要
Background: The detection rate of hyperuricemia is increasing, whose high incidence has brought great harm to public health. Available studies suggest that high uric acid is associated with chronic diseases, and increasing evidence supports that hyperuricemia may be a high risk factor for other chronic diseases. Objective; To analyze the association of hyperuricemia with common chronic diseases in middle-aged and elderly people. Methods: Data came from part of the 2015 China Health and Retirement Longitudinal Survey, involving 9 022 cases(>45 years old) with complete blood test information. Chi-square test was used to compare hyperuricemia prevalence in participants by demographic factors. Multivariate unconditional Logistic regression was used to examine the association between hyperuricemia with common chronic diseases. Results: A total of 1 117 cases(628 men and 489 women) were found with hyperuricemia, accounting for 12.38%. Men had higher hyperuricemia prevalence than women〔14.65%(628/4 287) vs 10.33%(489/4 735)〕(P<0.01). After adjusting for confounding factors, hyperuricemia was found to be associated with hypertension〔OR(95%CI)=1.621(1.399, 1.877)〕, hyperlipidemia〔OR(95%CI)=1.465(1.245, 1.724)〕 and digestive diseases〔OR(95%CI)=0.801(0.687, 0.934)〕, but had no association with diabetes, heart disease and stroke. In men with hyperuricemia, hyperuricemia was found to be associated with hypertension 〔OR(95%CI)=1.555(1.273, 1.899)〕, hyperlipidemia〔OR(95%CI)=1.510(1.203, 1.895)〕, diabetes〔OR(95%CI)=0.649(0.474, 0.890)〕 and digestive diseases〔OR(95%CI)=0.772(0.623, 0.957)〕. In women with hyperuricemia, hyperuricemia was associated with hypertension〔OR(95%CI)=1.696(1.363, 2.111)〕, and hyperlipidemia〔OR(95%CI)=1.452(1.146, 1.839)〕. Conclusion: Hyperuricemia may be associated with hypertension, hyperlipidemia, and digestive diseases in middle-aged and elderly people aged over 45 years. Men may be more prone to hyperuricemia. Effective interventions should be delivered to groups at high risk for hyperuricemia to reduce the morbidities of related chronic diseases.
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