Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study Efectos de la Asociaci車n de Estatina y del Ejercicio Aer車bico en los Cardiomiocitos de Rata: Estudio Morfom谷trico

作者：Susimary Aparecida Trevizan Padulla; Reinaldo Azoubel; Mariana Rotta Bonfim; Marilita Falangola Accioly

来源：International Journal of Morphology, 2009.

• Inhibidor hidroximetilglutaril CoA reductasa
• Ejercicio
• Nucleo de cardiomiocito
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Exercise
• Cardiomyocite nuclei

Physical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic physical exercise association in the morphometric parameters of cardiac cell nucleus. 40 male rats adults were divided into four groups: exercised (DE); sedentary (DS), exercised and statin use (DES); sedentary and statin use (DSS). The animals received during the whole experimental period a hiperlipidic diet added 20% of coconut oil and 1.25% of cholesterol; after 30 days of its ingesti車n, a blood collection was made to verify the dyslipidaemia. Simvastatin (20 mg) was taken five days a week, during eight weeks. During this period, the animals exercised 60 minutes daily in the treadmill. After the last day of the protocol, the cardiac muscle was collected and maintained in liquid nitrogen (-180～C); the cuts were stained by Hematoxilin-Eosin method, and the cardiac fibers were submitted to the nuclear morphometric analyses. The data were analyzed using descriptive analyses, paired T test, Kruskal-Wallis test and Dunn post hoc test; for all analyses, it was adopted p%26lt;0.05. It was verified that the group receiving statin presented values statistically significant in comparison to the other groups, in the tridimensional and linear variables. The exercised and statin group, the values obtained in the morphometric analyses were similar to the control group. It is suggested that statins alone can cause alterations in the nucleus of cardiac cells that can be related to apoptosis occurrence and, when exercise is practiced associated to statin administration, the effects of statin can be reduced, what can be related to beneficial adaptations of cardiac mitochondrial in response to physical exercise, turning them more resistant to apoptotic stimuli. El ejercicio f赤sico y las estatinas, intervenciones recomendadas para tratamiento de la dislipidemia, est芍n independientemente relacionadas con las alteraciones de los cardiomiocitos, que se caracterizan por hipertrofia mioc芍rdica y apoptosis, respectivamente. El objetivo del presente estudio fue analizar los efectos de la asociaci車n de estatinas y el ejercicio f赤sico aer車bico en los par芍metros morfom谷tricos del n迆cleo de c谷lulas card赤acas. 40 ratas macho adultas se dividieron en cuatro grupos: ejercitadas (DE); sedentarias (DS), ejercitadas y con uso de estatina (DES), sedentarias y con uso de estatina (DSS). Los animales r