科研之友
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摘要
objective: to compare children/adolescents with mild or moderate asthma and healthy subjects in terms of respiratory muscle strength, correlating it with spirometric variables in the former group. methods: this was a cross-sectional study involving individuals 6-16 years of age and clinically diagnosed with mild/moderate asthma, together with a group of healthy, age- and gender-matched subjects. we determined spirometric values, as well as mip and mep, and we selected three reproducible measurements (variation %26lt; 10%). results: we evaluated 75 patients with asthma and 90 controls. the mean age was 10.0 ㊣ 2.6 years. there were no statistically significant differences between the controls and the asthma group regarding mip (-89.7 ㊣ 26.7 cmh2o vs. -92.2 ㊣ 26.3 cmh2o; p = 0.541) or mep (79.2 ㊣ 22.9 cmh2o vs. 86.4 ㊣ 24.0 cmh2o; p = 0.256). the groups were subdivided by age (children and adolescents: 6-12 and 13-16 years of age, respectively). within the asthma group, there was a significant difference between the child and adolescent subgroups in terms of mep (74.1 ㊣ 24.1 cmh2o vs. 92.1 ㊣ 21.9 cmh2o; p %26lt; 0.001) but not mip (p = 0.285). within the control group, there were significant differences between the child and adolescent subgroups in terms of mip (-79.1 ㊣ 17.7 cmh2o vs. -100.9 ㊣ 28.1 cmh2o; p %26lt; 0.001) and mep (73.9 ㊣ 18.7 cmh2o vs. 90.9 ㊣ 28.1cmh2o; p %26lt; 0.001). in the asthma group, spirometric variables did not correlate with mip or mep. conclusions: in our sample, asthma was found to have no significant effect on respiratory muscle strength.
