乳酸与蛋白质乳酸化修饰:能量代谢的“丑小鸭”变为“蛋白质雕塑艺术家”(英文)

作者:李林鹏*; 孙山虎; 邬毅; 陆江焕; 何静彩; 陈可实; 陈伟仪; 刘兴国*
来源:Science Bulletin, 2023, 68(21): 2510-2514.

摘要

<正>Metabolites play important roles in numerous cell biology processes, such as cell proliferation, differentiation, stress response,and cell death [1]. Recently, lactate and lactate-derived lysine residue lactylation (Kla) have emerged as newly discovered epigenetic modifications that play critical roles in various physiological and pathological processes. In the history of lactate research, we can categorize the studies into three mile stones (Fig. S1 online).