Verbalide A～F: new phthalide derivatives from the endophytic fungus Preussia sp. CPCC 400972

作者：Zhang, Ran; Wang, Yujia; Cai, Guowei; Wang, Juxian; Zhao, Jianyuan; Bai, Jinglin; Zhang, Tao; Cen, Shan; He, Wenni^*; Yu, Liyan^*

来源：Journal of Antibiotics, 2023, 76(10): 613-617.

DOI：10.1038/s41429-023-00640-z

There are six new phthalide derivatives Verbalide A similar to F (1-6) together with another known derivative (7) isolated from the endophytic fungus Preussia sp. CPCC 400972. Their structures were established by comprehensive spectroscopic analyses, including NMR and HRESIMS. In addition, compounds 1-7 exhibited excellent inhibitory effect against influenza A virus.

• 单位
  北京协和医学院; 中国医学科学院医药生物技术研究所; 中国医学科学院北京协和医院