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ResumenIntroducci車nEl p谷ptido Sustancia P (SP) es el ligando principal de los receptores de neurokininas tipo 1, los cuales se encuentran sobreexpresados en los gliomas malignos.M谷todoSe obtuvo 177Lu-DOTA-SP con elevada pureza radioqu赤mica. Se realizaron biodistribuciones en ratones normales a diferentes tiempos. Se calcularon las dosis absorbidas para los diferentes 車rganos del rat車n (cGy/米Ci). Utilizando los m谷todos de escalaci車n por tiempo (A) y extrapolaci車n directa (B), se obtuvieron las dosis en los diferentes 車rganos humanos. Se calcularon las m芍ximas dosis tolerables en funci車n de los 車rganos cr赤ticos (mCi/kg).ResultadosLa m芍xima actividad tolerable que puede ser inyectada sin producir toxicidad en ri ones es 11,2 mCi/kg (hombre adulto) y 11,4 mCi/kg (mujer adulta) seg迆n el m谷todo A y de 47,2 mCi/kg y 56,2 mCi/kg, respectivamente seg迆n el m谷todo B.ConclusionesHasta el momento se pudo obtener 177Lu-DOTA-SP con Ae= 0,05mCi/ 米g de p谷ptido. La misma puede aumentarse utilizando el 177LuCl3 de mayor actividad espec赤fica.AbstractBackground99Tcm-MAG3 is a non-invasive method for the evaluation of renal transplants, giving information about allograft function and short- and long-term allograft survival. However, few studies have validated this observation.ObjetiveTo determine the predictive power of different scintigraphic parameters on graft survival at 6 -12 months after renal transplantation.MethodsBetween 1996-2007, receptors with varying degrees of kidney dysfunction were studied with 99mTc-MAG3 scintigraphy within 14 days after transplantation. Tubular injury score (TISS) ranging I-VI according to severity and renal extraction index (R20/3) were calculated. Survival analysis and Cox regression were used for analysis.ResultsThree-hundred and four renograms were performed in 146 allografts (143 receptors, mean age 38.9㊣17 years, 81.5% from cadaveric donor). Mean follow-up time was 44 months. There was graft loss (GL) in 32% renal trasplants. According to severity range, graft survival at 6 and 12 months was: TISS I-II 85.23% and 81.17%; TISS III-IV 82.43% and 80.56%, and TISS V-VI 32% and 2.,43% respectively. TISS score of V-VI score was an independent predictor for GL (HR = 6.3 CI 95% 2.9每13; p%26lt;0.0001). R20/3 index was not a good predictor of GL.ConclusionsTISS score was an independent predictor of short- and long-term allograft survival using 99mTc-MAG3 scintigraphy performed early after kidney transplantation in patients with suspected patients renal dysfunction. TISS V-VI had a greater discriminatory power. R20/3 index individually did not presen
