Amn谷sie ant谷rograde cons谷cutive 角 l＊absorption de MDMA et d＊alcool : 角 propos d＊un cas Anterograde amnesia following MDMA and alcohol absorption: report of a case

作者：Sastre Caroline; Cheze Marjorie; Baillif Couniou Valerie; Deveaux Marc

来源：Annales de Toxicologie Analytique, 2012.

DOI：10.1051/ata/2011136

• MDMA
• alcool
• amnesie anterograde
• soumission chimique
• MDMA
• alcohol
• anterograde amnesia
• drug-facilitated crime

Objectifs : Les auteurs rapportent un cas original d＊amn谷sie ant谷rograde cons谷cutive 角 l＊absorption concomitante d＊alcool et de MDMA. Patients et m谷thodes : Une jeune femme de 20 ans pr谷sente, au d谷cours d＊une soir谷e o迄 elle aurait consomm谷 de l＊alcool et de l＊ecstasy, une amn谷sie ant谷rograde totale jusqu＊au lendemain matin. Le dosage de l＊alcool dans le sang et l＊urine est r谷alis谷 par HS-GC-FID ; le dosage des amph谷tamines et mol谷cules apparent谷es est effectu谷 dans ces m那mes pr谷l豕vements par GC-MS et LC-MS/MS. La recherche des produits pouvant 那tre utilis谷s lors d＊une soumission chimique est r谷alis谷e dans les cheveux par GC-MS/MS et LC-MS/MS. R谷sultats : Le sang et l＊urine sont pr谷lev谷s 36 heures apr豕s. La recherche de l＊谷thanol est n谷gative dans le sang et l＊urine. La MDMA et la MDA ont 谷t谷 identifi谷es au niveau sanguin et urinaire. Dans les cheveux, la MDMA et la MDA ont 谷t谷 mises en 谷vidence 角 des concentrations respectives de 602 et 42 pg/mg uniquement au niveau du segment correspondant 角 la p谷riode des faits. Conclusion : Il s＊agit d＊un cas original d＊amn谷sie ant谷rograde secondaire 角 l＊association alcool-MDMA. Il confirme la n谷cessit谷 d＊谷tudier de fa on plus approfondie les effets de l＊association MDMA-alcool chez l＊Homme. Objectives: The authors report an unusual case of anterograde amnesia after concurrent ingestion of alcohol and MDMA. Patients and methods: A 20-year-old woman, after ingesting alcohol and ecstasy during the course of an evening, was reported to have suffered from anterograde amnesia until the next morning. Alcohol determination in blood and urine was performed by HS-GC-FID, while amphetamines were detected by GC-MS and LC-MS/MS. Hair analysis for the determination of drugs involved in drug-facilitated crimes was performed by GC-MS and LC-MS/MS. Results: Blood and urine were sampled 36 hours after the event. Alcohol was not detected in blood or urine. MDMA and MDA were identified in both blood and urine. MDMA and MDA were detected in hair at concentrations of 602 and 42 pg/mg, respectively, only in the segment corresponding to the period of the event. Conclusion: This is an unusual case of anterograde amnesia following concurrent use of alcohol and MDMA. This case underlines that it could be of great interest to study in more detail the effects of MDMA and alcohol in humans when taken concurrently.