INHIBITION OF TYPE I 5汐-REDUCTASE BY MEDICINAL PLANT EXTRACTS

作者：Patil Vijaya; Samuel Grace; Mirapurkar Shubhangi; R Krishna Mohan

来源：International Journal of Research in Ayurveda and Pharmacy, 2011.

• Type I 5&alpha
• -reductase
• acne
• MBC
• medicinal plants.

Type I 5汐-reductase has been implicated in skin disorders such as acne, hirsutism and male pattern baldness and its inhibition offers a potential treatment for these disorders. The aim of this study was to investigate the inhibition of type I 5汐-reductase activity by extracts from Indian medicinal plants. Plant extracts were screened and selected based on their ability to inhibit Propionibacterium acnes and Staphylococcus epidermidis. Since type I 5汐-reductase metabolises testosterone to 忖4-androstene-3, 17-dione, the activity of enzyme was determined using RIA for testosterone and 忖4-androstene-3, 17-dione. It was found that methanolic extract of Embelia ribes was a potent inhibitor of type I 5汐-reductase (IC50:100米g/mL). Extracts of Vitex negundo, Terminalia chebula, and Terminalia bellerica which also inhibited type I 5汐-reductase (IC50: 200-390 米g /mL). Therefore herbal formulation of these plant extracts may be used in the treatment of skin disorders involving type I 5汐-reductase.