抗精神病药在抑郁障碍治疗中的作用(英文)

作者：王平; 司天梅

来源：上海精神医学, 2013, 25(03): 134-140.

• 抗精神病药
• 抑郁障碍

There is a long history of using antipsychotic medications in the treatment of depressive disorders. Atypical antipsychotics, which have fewer side effects than traditional antipsychotics, have been used as monotherapy or adjunctively with antidepressants to treat depressive disorders with or without psychotic symptoms. The antidepressant effect of atypical antipsychotics involves regulation of monoamine, glutamate, gamma-aminobutyric acid (GABA), cortisol, and neurotrophic factors. To date, the United States Food and Drug Administration (USFDA) has approved aripiprazole and quetiapine slow-release tablets as adjunctive treatment for depressive disorders, and the combination of olanzapine and fluoxetine for the treatment of treatmentresistant depression.When using atypical antipsychoticsinthetreatmentofdepressedpatients,cliniciansneed tomonitorpatients for the emergence of advers eeffects including extrapyramidal symptoms(EPS),weightgain, and hyperglycemia.

• 单位
  北京大学