科研之友
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摘要
purpose: to verify the effect of consumption of grape extract isolated or combined with 汐-tocopherol supplementation on atherosclerosis model with apo e -/- mice. methods: after six weeks of atherogenic diet, apo e -/- mice were divided into the following groups: control, grape, tocopherol and grape plus tocopherol. the treatment progressed for 11 weeks when animals were submitted to euthanasia. results: all the treatments presented hypocholesterolemic effect with reduction of serum and liver cholesterol levels. this effect was parallel to an increase in the fecal excretion of cholesterol. there was also a higher fecal excretion of saturated fatty acids in groups receiving grape extract or 汐-tocopherol. all the groups treated presented a tendency to show higher levels of vitamin e. the fatty acid profile showed a tendency for monounsaturated fatty acid preservation after grape extract and 汐-tocopherol consumption. morphological analysis revealed a lower degree of evolution of the atherosclerotic plaque of the animals that were fed 汐-tocopherol combined with grape extract, even when no difference was found in the size of the largest lesion. conclusion: a synergistic effect between the polyphenols and 汐-tocopherol was observed, resulting in diminished evolution of atherosclerosis and a greater beneficial effect on atherosclerosis than the isolated consumption of antioxidants.
