Two new molecular biomarkers in human colorectal cancer [人结直肠癌中两种新分子生物标记物的筛选]

作者：Xu T.; Wang Y.^*; Zhao S.; Li Y.; Liu X.; Zhong S.; Peng H.; Qu J.; Sheng S.; Wang X.

来源：Journal of Shenzhen University Science and Engineering, 2018, 35(5): 529-535.

DOI：10.3724/SP.J.1249.2018.05529

• Biomarker
• Colorectal cancer
• Multiple immunohistochemistry
• Stomatin-like protein 1 (STOML1)
• TATA-box binding protein associated factor 1 like (TAF1L)
• Tissue microarray

In order to find new molecular biomarkers for early diagnose of colorectal cancer (CRC), we investigated the potential role of TATA-binding protein factor associated 1 like (TAF1L) and stomatin-like protein 1 (STOML1) in colorectal cancers and matched normal adjacent tissues by using tissue microarray with multiple immunohistochemical staining. Moreover, the relationship between TAF1L expressive level and deteriorated stages of CRC was also analyzed. The results showed that protein expression of TAF1L was significantly higher in CRC tissues than that in normal adjacent tissues (p<0.0001), and abnormal higher levels of TAF1L were significantly associated with the deterioration of CRC. In contrast, protein expression of STOML1 showed no statistical difference between colorectal cancer and normal adjacent tissue (p>0.05). The conclusion suggests that TAF1L overexpression is probably related to the occurrence and development of colorectal cancer, and may also be as a potential biomarker for early diagnosis, precision medicine and prognosis of colorectal cancer.