Subcellular localization and stability of MITF are modulated by the bHLH ‐Zip domain

作者：Valerie Fock; Sigurdur Runar Gudmundsson; Hilmar Orn Gunnlaugsson; Jon August Stefansson; Vivien Ionasz; Alexander Schepsky; Jade Viarigi; Indridi Einar Reynisson; Vivian Pogenberg; Matthias Wilmanns; Margret Helga Ogmundsdottir; Eirikur Steingrimsson

来源：Pigment Cell & Melanoma Research, 2019, 32(1): 41-54.

DOI：10.1111/pcmr.12721

• Nuclear localization
• Stability
• Waardenburg syndrome

Summary(#br)Microphthalmia‐associated transcription factor ( MITF ) is a member of the basic helix–loop–helix leucine zipper ( bHLH ‐Zip) family and functions as the master regulator of the melanocytic lineage. MITF ‐M is the predominant isoform expressed in melanocytes and melanoma cells, and, unli...