Avaliaˋˋo da associaˋˋo entre as alteraˋˋes no metabolismo mineral e o prurido nos pacientes em hemodi芍lise

作者：Welter; Elisangela de Quevedo; Frainer; Renata Hubner; Maldotti; Adriana; Losekann; Alexandre; Weber; Magda Blessmann

来源：Anais Brasileiros de Dermatologia, 2011.

DOI：10.1590/S0365-05962011000100003

• kidney failure
• chronic
• pruritus
• renal dialysis
• renal insufficiency
• chronic.

background: uremic pruritus is the most frequent symptom in long-term hemodialysis patients. abnormal laboratory parameters have been found with conflicting data. objective: to correlate the prevalence of pruritus with alterations in mineral metabolism in hemodialysis patients. methods: this was a case-control study. a hundred and five patients on maintenance hemodialysis were evaluated: a group of patients with pruritus and a control group. they answered a research protocol questionnaire; laboratory data were collected from medical records and the patients with pruritus filled out a visual analogue scale (vas) to measure pruritus level. results: the mean age was 51.9 years; 59% of the patients were men and 43% of the patients had pruritus. xeroderma occurred in 45% of the patients. high levels of calcium were demonstrated in 55% of the patients and 47% had pruritus. 60% of the patients had high phosphorus levels and 43% had pruritus. the ca/p ratio was normal for all the patients. parathyroid hormone was high in 95% of the patients, all of them referring pruritus. conclusion: there was a statistically significant association between the group of patients with pruritus and xeroderma. serum calcium and phosphorus levels, ca/p ratio, pthi and size of the dialyzer did not show a statistically significant association with pruritus. therefore, we found an important relationship between xeroderma and pruritus, with no relation with the assessed laboratory parameters.