科研之友
微信
新浪微博
Facebook
分享链接
摘要
Mitral valve cusps consist mainly of connective tissue and myocardium. Connective tissue fibres within the cusps have been demonstrated to exhibit sex variations in organisation. Mitral prolapse, a disease attributed to defects within the cusps occurs more commonly in females. Sex variations in valvular myocardium however remain to be studied. Possible variations in its organisation may enhance understanding of sex differences in prevalence of mitral prolapse. The aim of this study was to determine anatomical variations of mitral valvular myocardium by sex; by mean a comparative cross-sectional study. A total of 48 (27 male and 21 female) adult heart specimens obtained during autopsy at Nairobi City and Chiromo mortuaries after ethical approval were used. Valvular cusps were then harvested. Four - millimetre sections were made at the area of maximum width for both anterior and posterior cusps. These were processed for paraffin-embedding and sectioning and stained with Masson%26apos;s trichrome and Weigert%26apos;s resorcin fuchsin with Van Gieson counterstain to demonstrate cardiac muscle, collagen and elastic fibres. Both anterior and posterior cusps demonstrated three histological laminae, that is, atrialis, fibrosa and ventricularis. Only lamina atrialis contained cardiac muscle. This lamina in males was characterised by a transversely oriented subendothelial myocardial strip while that in females contained compact longitudinal elastic fibres but no muscle. The presence of cardiac muscle in the lamina atrialis may be relatively protective against mitral valve prolapse in males compared to females. Las c迆spides de la valva mitral est芍n constituidas principalmente por tejido conectivo y miocardio. Se ha demostrado que las fibras del tejido conectivo de las c迆spides presentan diferencias en la organizaci車n seg迆n sexo. El prolapso mitral, una enfermedad atribuida a defectos en las c迆spides es m芍s frecuente en las mujeres. Las variaciones de sexo en el miocardio valvular sin embargo a迆n no se han estudiado. Las posibles variaciones en su organizaci車n puede mejorar la comprensi車n de las diferencias de sexo en la prevalencia de prolapso mitral. El objetivo de este estudio fue determinar las variaciones anat車micas del miocardio valvar mitral por sexo, por medio un estudio comparativo de corte transversal. Un total de 48 los espec赤menes de coraz車n adulto (se utilizaron 27 hombres y 21 mujeres), obtenidos durante autopsias en la ciudad de Nairobi y desde el dep車sito de cad芍veres Chiromo, despu谷s de la aprobaci車n 谷tica. Las c迆spides valvares fueron extra赤das. Fueron realizada
