Re‐engineering the Immune Response to Metastatic Cancer: Antibody‐Recruiting Small Molecules Targeting the Urokinase Receptor

作者：Dr Anthony F Rullo; Kelly J Fitzgerald; Dr Viswanathan Muthusamy; Min Liu; Dr Cai Yuan; Prof Dr Mingdong Huang; Minsup Kim; Prof Dr Art E Cho; Prof Dr David A Spiegel

来源：Angewandte Chemie, 2016, 128(11): 3706-3710.

DOI：10.1002/ange.201510866

• Immunologie
• Medizinische Chemie
• Tumortherapeutika
• Wirkstoffentwicklung
• Zellerkennung

Abstract(#br)Developing selective strategies to treat metastatic cancers remains a significant challenge. Herein, we report the first antibody‐recruiting small molecule (ARM) that is capable of recognizing the urokinase‐type plasminogen activator receptor (uPAR), a uniquely overexpressed cancer cell...

• 单位
  yale university; 结构化学国家重点实验室; Yale School of Medicine