Arsenic-Containing Qinghuang Powder(青黄散) Is An Alternative Treatment for Elderly Acute Myeloid Leukemia Patients Refusing Low-Intensity Chemotherapy

作者：FAN Teng; QUAN Ri-cheng; LIU Wei-yi; XIAO Hai-yan; TANG Xu-dong; LIU Chi; LI Liu; LV Yan; WANG Hong-zhi; XU Yong-gang; GUO Xiao-qing; HU Xiao-mei

来源：Chinese Journal of Integrative Medicine, 2020, 26(05): 339-344.

Objective: To analyze the overall survival(OS) of elderly acute myeloid leukemia(AML) patients treated with oral arsenic-containing Qinghuang Powder(青黄散, QHP) or low-intensity chemotherapy(LIC). Methods: Forty-two elderly AML patients treated with intravenous or subcutaneous LIC(1 month for each course, at least 3 courses) or oral QHP(3 months for each course, at least 2 courses) were retrospectively analyzed from January 2015 to December 2017. The main endpoints of analysis were OS and 1-, 2-, 3-year OS rates of patients, respectively. And the adverse reactions induding bone marrow suppression, digestive tract discomfort and myocardia injury were observed. Results: Out of 42 elderly AML patients, 22 received LIC treatment and 20 received QHP treatment, according to patients’ preference. There was no significant difference on OS between LIC and QHP patients(13.0 months vs. 13.5 months, P>0.05). There was no significant difference on OS rates between LIC and QHP groups at 1 year(59.1% vs. 70.0%), 2 years(13.6% vs. 15%), and 3 years(4.6% vs. 5.0%, all P>0.05). Furthermore, there was no significant difference of OS on prognosis stratification of performance status > 2(12 months vs. 12 months), age> 75 year-old(12.0 months vs. 12.5 months), hematopoietic stem cell transplant comorbidity index >2(12 months vs. 13 months), poor cytogenetics(12 months vs. 8 months), and diagnosis of secondary AML(10 months vs. 14 months) between LIC and QHP patients(P>0.05). Conclusion: QHP may be an alternative treatment for elderly AML patients refusing LIC therapy.

• 单位
  中医学科学院