Effects of Travoprost on conjunctival vascular density and blood flow velocity

作者：Ye, Lei; Liu, Kangcheng; Luo, Zhongzhou; Rong, Rong; Zhong, Jing; Jiang, Nan; Zhou, Xuezhi; Yuan, Qing; Ma, Mingyang; Zhu, Peiwen; Shao, Yi^*

来源：International Journal of Clinical and Experimental Medicine, 2018, 11(3): 2414-2421.

• Conjunctiva
• vascular density
• blood flow velocity
• functional slit lamp biomicroscopy
• optical coherence tomography angiography
• travoprost

Aim: The conjunctiva hemodynamics changes lead to vascular dysfunction and pathophysiological changes. We aimed to evaluate the effect of Travoprost eye drops on conjunctival vascular density and blood flow velocity in healthy individuals. Methods: We recruited 16 healthy subjects treated with Travoprost eye drops (one of the prostaglandin analogs) and used functional slit lamp biomicroscopy (FSLB) to image the conjunctival noninvasive microvascular perfusion maps (nMPMs) and assess the hemodynamics. The high-speed camera sets at a high imaging rate of 60 frames per second and an up to 210x high magnification to achieve the hemodynamics. Fractal analysis of conjunctival nMPMs was analysed by customized software to measure both the blood flow velocity and the vascular density of the upper, lower, nasal, and temporal sides of each subject. We used the optical coherence tomography angiography (OCTA) to obtain the blood vessel images on both the left and right sides of each subject. The blood vessel density of both sides was measured and analyzed individually. Results: The vascular density of the lower side significantly increased after 6 hours of the Travoprost eye drops treatment (p < 0.05); however, the vascular density of the upper, nasal, and temporal sides, both the left and right sides were not in significant difference (p > 0.05). The FSLB and OCTA results were not significantly different in the conjunctival microvessel density (p > 0.05). The blood flow velocity increased slightly (p > 0.05). The blood flow velocity increased significantly after six hours and less obvious after 12 hours and was back to normal after 24 hours. The blood flow velocity of the lower side significantly increased with Travoprost eye drops treatment after six hours (p < 0.05); however, the vascular density of the upper, nasal, and temporal sides were not significantly different before the treatment and after six hours, 12 hours and 24 hours (p > 0.05). The blood vessel velocity between the left and right eyes was not significantly different (p > 0.05). Conclusions: In healthy individuals, Travoprost eye drops treatment could slow down the conjunctival blood flow velocity after a short period of time and has no significant effect on vascular density.

• 单位
  中山大学; 南昌大学