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摘要
AIM: To investigate the correlation between the concentrations of interleukin-23 (IL-23) and interleukin-17 (IL-17) in the ocular aqueous humor (AH) at the different degrees of diabetic retinopathy (DR) patients. METHODS: From June 2016 to June 2019, 70 patients (70 eyes) for age related cataract surgery were enrolled in Hubei Yichang Central People's Hospital. All cases were graded into 4 groups, includingⅠ group (20 cases): the control group (patients without diabetes), Ⅱ group (18 cases): diabetic patients without retinopathy, Ⅲ group (17 cases): diabetic patients with non-proliferative diabetic retinopathy, Ⅳ group (15 cases): diabetic patients with proliferative diabetic retinopathy. The levels of IL-23 and IL-17 in AH of the four groups were tested by Enzyme-linked immunosorbent assay (ELISA) and statistically analyzed by ANOVA respectively. The correlations between IL-17 and IL-23 were calculated by Person correction analysis. RESULTS: The concentration of IL-23 in Ⅰgroup was low (22.18±5.48pg/mL),while those in Ⅱ (37.63±4.52pg/mL), Ⅲ (45.06±4.64pg/mL), Ⅳ (68.89±6.11pg/mL) groups respectively were higher. The IL-17 level inⅠ, Ⅱ, Ⅲ, Ⅳ groups were 4.69±2.03, 6.83±1.02, 9.52±1.30, 10.89±1.26pg/mL respectively. Comparison of IL-23 and IL-17 within four groups revealed: both were increased in Ⅱ group initially, and raised along with the progression of DR. According to the correlation analysis, the expression level of IL-17 of DM was typical positively correlated with IL-23. CONCLUSION: The over-expression of IL-23 and IL-17 may have a synergistic effect on the occurrence and development, and the IL-23/IL-17 pathway might be associated with the severity of DR by aggravating the inflammatory response of retina. These results indicated that IL-23-IL-17 axis could be a new target for the early diagnosis and treatment of DR.
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