科研之友
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摘要
More and more studies have found that hypercoagulable state and inflammatory reaction exist in the gastrointestinal system of patients with ulcerative colitis (UC), however, the correlation with platelet (PLT), fibrinogen (FIB) and D-dimer levels is unclear. Aims: To investigate the correlation of PLT, FIB, D-dimer with UC. Methods: Eighty-five UC patients from August 2015 to October 2017 at the Fourth Affiliated Hospital of Harbin Medical University were enrolled, and were divided into active UC and remission UC according to modified Mayo scoring system, and active UC were further divided into mild, moderate and severe groups. Fifty-three healthy subjects were served as controls. Levels of peripheral blood PLT, FIB, D-dimer were compared, and their correlations with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were analyzed. Results: Levels of PLT, FIB, D-dimer, CRP and ESR were gradually decreased from active UC group, remission UC group to control group (P<0.05). The levels of PLT, FIB, D-dimer, CRP and ESR were significantly decreased in mild group than in moderate group and severe group (P<0.05). The levels of FIB, D-dimer and CRP were significantly decreased in moderate group than in severe group (P<0.05). Spearman correlation analysis showed that PLT, FIB, D-dimer were positively correlated with staging, severity of UC, CRP and ESR (P<0.05). Conclusions: PLT, FIB and D-dimer are positively correlated with staging, severity of UC, and can be used as indices reflecting staging, severity of UC. COPYRIGHT ? 2018 by the Editorial Office of Chinese Journal of Gastroenterology.
